Prison Break consists of 90 total episodes (including the "The Final Break" special) across five main seasons. Series Overview Original Air Dates Prison Setting Aug 2005 – May 2006 Fox River State Penitentiary (USA) Aug 2006 – Apr 2007 On the run across the USA and Panama Sep 2007 – Feb 2008 Penitenciaría Federal de Sona (Panama) Sep 2008 – May 2009 Los Angeles / Miami Apr 2017 – May 2017 Ogygia Prison (Yemen)
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