| Parameter | Meaning | Typical use | |-----------|---------|--------------| | AUC(0-t) | Total exposure from time 0 to last measurable conc. | Compare total drug absorption | | AUC(0-inf) | Extrapolated total exposure | IV bioavailability | | Cmax | Peak concentration | Safety/efficacy peak | | t½ | Elimination half-life | Dosing interval design | | CL/F | Apparent clearance | Dose adjustment |
Specifically designed for non-clinical studies, this module handled sparse sampling designs common in animal toxicology. It calculated exposure margins and accumulation ratios.
Speeds up the release process through automated quality checks.