If DmC: Devil May Cry on Steam refuses to launch with the error “Steam must be running to play this game,” try these steps in order. Follow each section until the game launches.
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Go to the game's installation folder (Right-click in Steam > Manage > ). If DmC: Devil May Cry on Steam refuses
This is the most common fix. If Steam is running with normal privileges but the game tries to access system-level files, the handshake fails. If DmC: Devil May Cry on Steam refuses
Right-click the game executable ( DMC-DevilMayCry.exe ) > > Compatibility .