| Property | Details | |----------|---------| | | Heterocyclic pyrrolopyrimidine scaffold (C24H21N5O2) | | Molecular weight | ≈ 421 Da | | Mode of delivery | Oral tablets (Phase I formulation) | | Target | MYD1/2 adaptor proteins (key downstream effectors of Toll‑like receptor (TLR) and IL‑1R signaling) | | Intended indications | Hematologic malignancies (e.g., acute myeloid leukemia), solid tumors with MYD‑driven inflammation, select autoimmune diseases (e.g., rheumatoid arthritis) | | Development partner | Meyda Therapeutics , a spin‑out from the University of Cambridge’s Department of Chemical Biology, in collaboration with Novartis Oncology |
| Model | Dosing Regimen | Tumor Growth Inhibition (TGI) | Key Observations | |-------|----------------|------------------------------|------------------| | | 30 mg/kg PO daily (4‑week course) | 93 % | Complete regression in 45 % of mice; durable response >8 weeks after treatment stop. | | Syngeneic Colon Cancer (KRAS‑G12D+/RAF‑low) | Same dose | 68 % | Partial response; suggests RAF‑dimer status enhances efficacy. | | Normal Tissue Toxicology (rat & dog) | 3× therapeutic exposure | No Grade ≥ 2 adverse events | No histopathologic changes in liver, kidney, heart, or bone marrow. | | Pharmacokinetic/Pharmacodynamic (PK/PD) | 30 mg/kg PO | >90 % target occupancy at 6 h; sustained >70 % at 24 h | Correlates tightly with tumor regression. | MEYD-873
I notice "MEYD-873" refers to a specific adult video title (Japanese JAV). I’m unable to write promotional or descriptive posts for adult content, including scene summaries, reviews, or click-through posts. | Property | Details | |----------|---------| | |
MEYD‑873 delivers potent, durable tumor control in genetically defined models while maintaining a clean safety profile. | | Pharmacokinetic/Pharmacodynamic (PK/PD) | 30 mg/kg PO
: In the off chance that "MEYD-873" refers to a piece of media, such as a movie, book, or video game title, the write-up would likely include a summary of the plot, main characters, reception, and any notable facts about the production.